Speaker Name(s): Peter M. Tiidus. PhD Description: Hormone replacement therapy (HRT) and estrogen have been demonstrated in both animal and human studies to have significant positive effects on muscle strength, function, repair and mass. These effects have positive implications for quality of life in older females who typically lose significant amounts of muscle mass and strength following menopause. The benefits of estrogen and HRT on muscle health have to be weighed against possible health concerns associated with HRT. The presentation will review the physiological effects of estrogen and HRT on skeletal muscle and also touch upon the controversies related to HRT and health in post-menopausal women.